145 MLB Players debut in 1980
| # | Player | debut Date |
|---|---|---|
| 1. | Luis Aguayo | 4/19/1980 |
| 2. | Kim Allen | 9/2/1980 |
| 3. | Luis Aponte | 9/4/1980 |
| 4. | Mike Armstrong | 8/12/1980 |
| 5. | Wally Backman | 9/2/1980 |
| 6. | Harold Baines | 4/10/1980 |
| 7. | Dave Beard | 7/16/1980 |
| 8. | Bruce Berenyi | 7/5/1980 |
| 9. | Mike Boddicker | 10/4/1980 |
| 10. | Bobby Bonner | 9/12/1980 |
| 11. | Rich Bordi | 7/16/1980 |
| 12. | Bill Bordley | 6/30/1980 |
| 13. | Chris Bourjos | 8/31/1980 |
| 14. | Marshall Brant | 10/1/1980 |
| 15. | Fred Breining | 9/4/1980 |
| 16. | Hubie Brooks | 9/4/1980 |
| 17. | Mark Brouhard | 4/12/1980 |
| 18. | John Butcher | 9/8/1980 |
| 19. | Sal Butera | 4/10/1980 |
| 20. | Marty Bystrom | 9/7/1980 |
| 21. | Ernie Camacho | 5/22/1980 |
| 22. | Manny Castillo | 9/1/1980 |
| 23. | Joe Charboneau | 4/11/1980 |
| 24. | Stan Cliburn | 5/6/1980 |
| 25. | Geoff Combe | 9/2/1980 |
| 26. | Onix Concepcion | 8/30/1980 |
| 27. | Nardi Contreras | 5/23/1980 |
| 28. | Gary Cooper | 8/25/1980 |
| 29. | Doug Corbett | 4/10/1980 |
| 30. | Ray Cosey | 4/14/1980 |
| 31. | Jeff Cox | 7/1/1980 |
| 32. | Steve Crawford | 9/2/1980 |
| 33. | Odie Davis | 9/3/1980 |
| 34. | Mike Davis | 4/10/1980 |
| 35. | Mark Davis | 9/12/1980 |
| 36. | Bob Dernier | 9/7/1980 |
| 37. | Joe DeSa | 9/6/1980 |
| 38. | Bob Detherage | 4/11/1980 |
| 39. | Jim Dorsey | 9/2/1980 |
| 40. | Leon Durham | 5/27/1980 |
| 41. | Jerry Dybzinski | 4/11/1980 |
| 42. | Dave Edler | 9/4/1980 |
| 43. | Lenny Faedo | 9/6/1980 |
| 44. | Jesus Figueroa | 4/22/1980 |
| 45. | Rich Gedman | 9/7/1980 |
| 46. | Alan Hargesheimer | 7/14/1980 |
| 47. | Terry Harper | 9/12/1980 |
| 48. | Mike Hart | 6/12/1980 |
| 49. | Bill Hayes | 9/30/1980 |
| 50. | Drungo Hazewood | 9/19/1980 |
| 51. | Paul Hodgson | 8/31/1980 |
| 52. | Glenn Hoffman | 4/12/1980 |
| 53. | Scott Holman | 9/20/1980 |
| 54. | Roger Holt | 10/4/1980 |
| 55. | Paul Householder | 8/26/1980 |
| 56. | Steve Howe | 4/11/1980 |
| 57. | Jay Howell | 8/10/1980 |
| 58. | Bruce Hurst | 4/12/1980 |
| 59. | Orlando Isales | 9/11/1980 |
| 60. | Randy Johnson | 7/5/1980 |
| 61. | Jeff Jones | 4/10/1980 |
| 62. | Mike Jones | 9/6/1980 |
| 63. | Don Kainer | 9/6/1980 |
| 64. | Rickey Keeton | 5/27/1980 |
| 65. | Pat Kelly | 5/28/1980 |
| 66. | Mike Kinnunen | 6/12/1980 |
| 67. | Gil Kubski | 9/2/1980 |
| 68. | Tito Landrum | 7/23/1980 |
| 69. | Dave LaPoint | 9/10/1980 |
| 70. | Vance Law | 6/1/1980 |
| 71. | Charlie Lea | 6/12/1980 |
| 72. | Luis Leal | 5/25/1980 |
| 73. | Joe Lefebvre | 5/22/1980 |
| 74. | Carlos Lezcano | 4/10/1980 |
| 75. | Jeff Little | 9/6/1980 |
| 76. | John Littlefield | 6/8/1980 |
| 77. | Tim Lollar | 6/28/1980 |
| 78. | Scott Loucks | 9/1/1980 |
| 79. | Jay Loviglio | 9/2/1980 |
| 80. | Gary Lucas | 4/16/1980 |
| 81. | Ed Lynch | 8/31/1980 |
| 82. | Rick Lysander | 4/12/1980 |
| 83. | Keith MacWhorter | 5/10/1980 |
| 84. | John Martin | 8/27/1980 |
| 85. | Freddie Martinez | 4/20/1980 |
| 86. | Randy Martz | 9/6/1980 |
| 87. | Don McCormack | 9/30/1980 |
| 88. | Brad Mills | 6/8/1980 |
| 89. | Eddie Milner | 9/2/1980 |
| 90. | Bobby Mitchell | 9/1/1980 |
| 91. | Jose Moreno | 5/24/1980 |
| 92. | Lloyd Moseby | 5/24/1980 |
| 93. | Fran Mullins | 9/1/1980 |
| 94. | Scott Munninghoff | 4/13/1980 |
| 95. | Rich Murray | 6/7/1980 |
| 96. | Reid Nichols | 9/16/1980 |
| 97. | Bob Ojeda | 7/13/1980 |
| 98. | Al Olmsted | 9/12/1980 |
| 99. | Bob Pate | 6/2/1980 |
| 100. | Tony Pena | 9/1/1980 |
| 101. | Jack Perconte | 9/13/1980 |
| 102. | Pascual Perez | 5/7/1980 |
| 103. | Joe Pettini | 7/10/1980 |
| 104. | Ken Phelps | 9/20/1980 |
| 105. | Joe Price | 6/14/1980 |
| 106. | Mario Ramirez | 4/25/1980 |
| 107. | Rafael Ramirez | 8/4/1980 |
| 108. | Steve Ratzer | 10/5/1980 |
| 109. | Floyd Rayford | 4/17/1980 |
| 110. | Mike Richardt | 8/30/1980 |
| 111. | Andy Rincon | 9/15/1980 |
| 112. | Mike Rowland | 7/25/1980 |
| 113. | Luis Salazar | 8/15/1980 |
| 114. | Ken Schrom | 8/8/1980 |
| 115. | Mike Scioscia | 4/20/1980 |
| 116. | Rod Scurry | 4/17/1980 |
| 117. | Ricky Seilheimer | 7/5/1980 |
| 118. | Dave Smith | 4/11/1980 |
| 119. | Lee Smith | 9/1/1980 |
| 120. | Mark Souza | 4/22/1980 |
| 121. | George Stablein | 9/20/1980 |
| 122. | Dave Stapleton | 5/30/1980 |
| 123. | Jeff Stember | 8/5/1980 |
| 124. | Craig Stimac | 8/12/1980 |
| 125. | Guy Sularz | 9/2/1980 |
| 126. | Leo Sutherland | 8/11/1980 |
| 127. | Jim Tracy | 7/20/1980 |
| 128. | Jeff Twitty | 7/5/1980 |
| 129. | Jerry Ujdur | 8/17/1980 |
| 130. | Julio Valdez | 9/2/1980 |
| 131. | Fernando Valenzuela | 9/15/1980 |
| 132. | Bob Veselic | 9/18/1980 |
| 133. | Ozzie Virgil | 10/5/1980 |
| 134. | George Vukovich | 4/13/1980 |
| 135. | Bob Walk | 5/26/1980 |
| 136. | Chico Walker | 9/2/1980 |
| 137. | Tim Wallach | 9/6/1980 |
| 138. | Ty Waller | 9/6/1980 |
| 139. | Reggie Walton | 6/13/1980 |
| 140. | Roger Weaver | 6/6/1980 |
| 141. | Gary Weiss | 9/13/1980 |
| 142. | Dan Whitmer | 7/20/1980 |
| 143. | Albert Williams | 5/7/1980 |
| 144. | Mookie Wilson | 9/2/1980 |
| 145. | Ned Yost | 4/12/1980 |
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