198 MLB Players debut on April 22
| # | Player | debut Date |
|---|---|---|
| 1. | Spencer Adams | 4/22/1923 |
| 2. | Roberto Alomar | 4/22/1988 |
| 3. | Harry Aubrey | 4/22/1903 |
| 4. | Jay Avrea | 4/22/1950 |
| 5. | Jim Bagby | 4/22/1912 |
| 6. | Steve Balboni | 4/22/1981 |
| 7. | Frank Baldwin | 4/22/1953 |
| 8. | Johnny Berardino | 4/22/1939 |
| 9. | Jack Berly | 4/22/1924 |
| 10. | Carlos Bernier | 4/22/1953 |
| 11. | Claude Berry | 4/22/1904 |
| 12. | Charlie Bicknell | 4/22/1948 |
| 13. | Ping Bodie | 4/22/1911 |
| 14. | Julio Bonetti | 4/22/1937 |
| 15. | Ike Boone | 4/22/1922 |
| 16. | Bob Borkowski | 4/22/1950 |
| 17. | John Bottarini | 4/22/1937 |
| 18. | Jim Bouton | 4/22/1962 |
| 19. | Bill Boyd | 4/22/1872 |
| 20. | Harry Brecheen | 4/22/1940 |
| 21. | Jesse Burkett | 4/22/1890 |
| 22. | Wayne Cage | 4/22/1978 |
| 23. | Dick Calmus | 4/22/1963 |
| 24. | Howie Camnitz | 4/22/1904 |
| 25. | Al Cicotte | 4/22/1957 |
| 26. | Jose Cisnero | 4/22/2013 |
| 27. | Rickey Clark | 4/22/1967 |
| 28. | Al Clauss | 4/22/1913 |
| 29. | Jack Clements | 4/22/1884 |
| 30. | Verne Clemons | 4/22/1916 |
| 31. | Lou Clinton | 4/22/1960 |
| 32. | Ed Cole | 4/22/1938 |
| 33. | Ray Coleman | 4/22/1947 |
| 34. | Dick Conger | 4/22/1940 |
| 35. | Dale Coogan | 4/22/1950 |
| 36. | Barry Cort | 4/22/1977 |
| 37. | Roscoe Coughlin | 4/22/1890 |
| 38. | Fritz Coumbe | 4/22/1914 |
| 39. | Glenn Crawford | 4/22/1945 |
| 40. | Jack Creel | 4/22/1945 |
| 41. | Amos Cross | 4/22/1885 |
| 42. | Noel Cuevas | 4/22/2018 |
| 43. | Candy Cummings | 4/22/1872 |
| 44. | Jack Curtis | 4/22/1961 |
| 45. | Bill Dahlen | 4/22/1891 |
| 46. | George Darrow | 4/22/1934 |
| 47. | Frank Dasso | 4/22/1945 |
| 48. | Harold Daugherty | 4/22/1951 |
| 49. | Otis Davis | 4/22/1946 |
| 50. | Ira Davis | 4/22/1899 |
| 51. | Dave DeBusschere | 4/22/1962 |
| 52. | Wheezer Dell | 4/22/1912 |
| 53. | R. A. Dickey | 4/22/2001 |
| 54. | Bill Dinneen | 4/22/1898 |
| 55. | Bill Donovan | 4/22/1898 |
| 56. | Harry Eells | 4/22/1906 |
| 57. | Phil Ervin | 4/22/2017 |
| 58. | Mark Esser | 4/22/1979 |
| 59. | Homer Ezzell | 4/22/1923 |
| 60. | Jesus Figueroa | 4/22/1980 |
| 61. | Les Fleming | 4/22/1939 |
| 62. | John Flynn | 4/22/1910 |
| 63. | Bill Fouser | 4/22/1876 |
| 64. | Bill Froats | 4/22/1955 |
| 65. | Billy Gardner | 4/22/1954 |
| 66. | Ford Garrison | 4/22/1943 |
| 67. | Doc Gessler | 4/22/1903 |
| 68. | Frank Gibson | 4/22/1913 |
| 69. | Chad Girodo | 4/22/2016 |
| 70. | Johnny Gorsica | 4/22/1940 |
| 71. | Billy Grabarkewitz | 4/22/1969 |
| 72. | Matt Grace | 4/22/2015 |
| 73. | Lou Grasmick | 4/22/1948 |
| 74. | Ed Green | 4/22/1890 |
| 75. | Connie Grob | 4/22/1956 |
| 76. | Harley Grossman | 4/22/1952 |
| 77. | Mickey Haefner | 4/22/1943 |
| 78. | Brad Harman | 4/22/2008 |
| 79. | Bill Harris | 4/22/1923 |
| 80. | Wynn Hawkins | 4/22/1960 |
| 81. | Clarence Heise | 4/22/1934 |
| 82. | Nat Hicks | 4/22/1872 |
| 83. | Hob Hiller | 4/22/1920 |
| 84. | Derek Holland | 4/22/2009 |
| 85. | Fred House | 4/22/1913 |
| 86. | Mickey Hughes | 4/22/1888 |
| 87. | Billy Johnson | 4/22/1943 |
| 88. | Henry Jones | 4/22/1890 |
| 89. | Howie Judson | 4/22/1948 |
| 90. | Leo Kavanagh | 4/22/1914 |
| 91. | Charlie Keller | 4/22/1939 |
| 92. | John Kennedy | 4/22/1957 |
| 93. | Doc Kerr | 4/22/1914 |
| 94. | Pip Koehler | 4/22/1925 |
| 95. | Hal Kolstad | 4/22/1962 |
| 96. | Clayton Lambert | 4/22/1946 |
| 97. | Johnny Lazor | 4/22/1943 |
| 98. | Gene Leek | 4/22/1959 |
| 99. | Arnold Leon | 4/22/2015 |
| 100. | Horace Leverette | 4/22/1920 |
| 101. | Glenn Liebhardt | 4/22/1930 |
| 102. | Lou Limmer | 4/22/1951 |
| 103. | Em Lindbeck | 4/22/1960 |
| 104. | Joe Lonnett | 4/22/1956 |
| 105. | Mike Magnante | 4/22/1991 |
| 106. | Al Mahon | 4/22/1930 |
| 107. | Barney Martin | 4/22/1953 |
| 108. | Joe Marty | 4/22/1937 |
| 109. | J. J. Matijevic | 4/22/2022 |
| 110. | Ralph Mattis | 4/22/1914 |
| 111. | Phil McCullough | 4/22/1942 |
| 112. | Dan McGeehan | 4/22/1911 |
| 113. | Mickey McGowan | 4/22/1948 |
| 114. | Dave McKeough | 4/22/1890 |
| 115. | Henry Mercedes | 4/22/1992 |
| 116. | Lloyd Merritt | 4/22/1957 |
| 117. | Frank Metha | 4/22/1940 |
| 118. | Bob Milliken | 4/22/1953 |
| 119. | Vinegar Bend Mizell | 4/22/1952 |
| 120. | Les Munns | 4/22/1934 |
| 121. | Morgan Murphy | 4/22/1890 |
| 122. | Tom Nagle | 4/22/1890 |
| 123. | Al Niehaus | 4/22/1925 |
| 124. | Prince Oana | 4/22/1934 |
| 125. | Heinie Odom | 4/22/1925 |
| 126. | Monte Pearson | 4/22/1932 |
| 127. | Eddie Pellagrini | 4/22/1946 |
| 128. | Wily Peralta | 4/22/2012 |
| 129. | Jonathan Pettibone | 4/22/2013 |
| 130. | Wiley Piatt | 4/22/1898 |
| 131. | Clarence Pickrel | 4/22/1933 |
| 132. | Hugh Poland | 4/22/1943 |
| 133. | Al Porto | 4/22/1948 |
| 134. | Sam Post | 4/22/1922 |
| 135. | Bret Prinz | 4/22/2001 |
| 136. | Frankie Pytlak | 4/22/1932 |
| 137. | Ed Rakow | 4/22/1960 |
| 138. | Jack Redmond | 4/22/1935 |
| 139. | Bob Reece | 4/22/1978 |
| 140. | Xavier Rescigno | 4/22/1943 |
| 141. | John Rheinecker | 4/22/2006 |
| 142. | Billy Rhines | 4/22/1890 |
| 143. | Woody Rich | 4/22/1939 |
| 144. | John Richmond | 4/22/1875 |
| 145. | Claude Ritchey | 4/22/1897 |
| 146. | Rabbit Robinson | 4/22/1903 |
| 147. | Bob Rothel | 4/22/1945 |
| 148. | Bob Rush | 4/22/1948 |
| 149. | Gene Rye | 4/22/1931 |
| 150. | Manny Salvo | 4/22/1939 |
| 151. | Gregory Santos | 4/22/2021 |
| 152. | Jerry Scala | 4/22/1948 |
| 153. | Owen Scheetz | 4/22/1943 |
| 154. | John Scott | 4/22/1914 |
| 155. | Cy Seymour | 4/22/1896 |
| 156. | Jack Sharrott | 4/22/1890 |
| 157. | Andy Sheets | 4/22/1996 |
| 158. | Bill Sherdel | 4/22/1918 |
| 159. | Garland Shifflett | 4/22/1957 |
| 160. | John Simmons | 4/22/1949 |
| 161. | Tony Sipp | 4/22/2009 |
| 162. | Brian Slocum | 4/22/2006 |
| 163. | Bob Smith | 4/22/1958 |
| 164. | Frank Smith | 4/22/1904 |
| 165. | Chief Sockalexis | 4/22/1897 |
| 166. | Vic Sorrell | 4/22/1928 |
| 167. | Mark Souza | 4/22/1980 |
| 168. | Harry Steinfeldt | 4/22/1898 |
| 169. | Dick Stigman | 4/22/1960 |
| 170. | Snuffy Stirnweiss | 4/22/1943 |
| 171. | Elmer Stricklett | 4/22/1904 |
| 172. | Denny Sullivan | 4/22/1905 |
| 173. | Jim Sullivan | 4/22/1891 |
| 174. | Lee Tannehill | 4/22/1903 |
| 175. | Fred Thomas | 4/22/1918 |
| 176. | Lee Thomas | 4/22/1961 |
| 177. | Gleyber Torres | 4/22/2018 |
| 178. | Paul Toth | 4/22/1962 |
| 179. | Bob Trowbridge | 4/22/1956 |
| 180. | Tanner Tully | 4/22/2022 |
| 181. | Johnny Vander Meer | 4/22/1937 |
| 182. | Jamie Vermilyea | 4/22/2007 |
| 183. | Lee Viau | 4/22/1888 |
| 184. | Jake Wade | 4/22/1936 |
| 185. | Paul Wanninger | 4/22/1925 |
| 186. | Brandon Webb | 4/22/2003 |
| 187. | Thad Weber | 4/22/2012 |
| 188. | Bill Werle | 4/22/1949 |
| 189. | Bert Whaling | 4/22/1913 |
| 190. | Doc White | 4/22/1901 |
| 191. | Hal White | 4/22/1941 |
| 192. | Aldon Wilkie | 4/22/1941 |
| 193. | Jim Willis | 4/22/1953 |
| 194. | Craig Wilson | 4/22/2001 |
| 195. | George Woodend | 4/22/1944 |
| 196. | Ron Woods | 4/22/1969 |
| 197. | Jim Wright | 4/22/1981 |
| 198. | Joe Yeager | 4/22/1898 |
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