21 MLB Players debut in 1878
| # | Player | debut Date |
|---|---|---|
| 1. | Charlie Bennett | 5/1/1878 |
| 2. | Frank Bliss | 6/20/1878 |
| 3. | Fred Corey | 5/1/1878 |
| 4. | George Creamer | 5/1/1878 |
| 5. | Abner Dalrymple | 5/1/1878 |
| 6. | Buttercup Dickerson | 7/15/1878 |
| 7. | Jake Goodman | 5/2/1878 |
| 8. | Frank Hankinson | 5/1/1878 |
| 9. | Tom Healey | 6/13/1878 |
| 10. | Alamazoo Jennings | 8/15/1878 |
| 11. | King Kelly | 5/1/1878 |
| 12. | Bill McClellan | 5/20/1878 |
| 13. | Jim McCormick | 5/20/1878 |
| 14. | Russ McKelvy | 5/1/1878 |
| 15. | The Only Nolan | 5/1/1878 |
| 16. | Phil Powers | 8/31/1878 |
| 17. | Bill Sullivan | 8/9/1878 |
| 18. | Bill Traffley | 7/27/1878 |
| 19. | John Ward | 7/15/1878 |
| 20. | Harry Wheeler | 6/19/1878 |
| 21. | Ed Williamson | 5/1/1878 |
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