146 MLB Players debut in 1981
| # | Player | debut Date |
|---|---|---|
| 1. | Juan Agosto | 9/7/1981 |
| 2. | Jose Alvarez | 10/1/1981 |
| 3. | Shooty Babitt | 4/9/1981 |
| 4. | Howard Bailey | 4/12/1981 |
| 5. | Steve Balboni | 4/22/1981 |
| 6. | Chris Bando | 8/13/1981 |
| 7. | Jesse Barfield | 9/3/1981 |
| 8. | Steve Bedrosian | 8/14/1981 |
| 9. | George Bell | 4/9/1981 |
| 10. | Buddy Black | 9/5/1981 |
| 11. | Juan Bonilla | 4/9/1981 |
| 12. | Danny Boone | 4/11/1981 |
| 13. | Mark Bradley | 9/3/1981 |
| 14. | Bob Brenly | 8/14/1981 |
| 15. | Tom Brennan | 9/5/1981 |
| 16. | Darrell Brown | 4/11/1981 |
| 17. | Scott Brown | 8/11/1981 |
| 18. | Glenn Brummer | 5/25/1981 |
| 19. | Tom Brunansky | 4/9/1981 |
| 20. | Brett Butler | 8/20/1981 |
| 21. | George Cappuzzello | 5/31/1981 |
| 22. | Marty Castillo | 8/19/1981 |
| 23. | Bryan Clark | 4/11/1981 |
| 24. | Don Cooper | 4/9/1981 |
| 25. | Chili Davis | 4/10/1981 |
| 26. | Jody Davis | 4/21/1981 |
| 27. | Luis DeLeon | 9/6/1981 |
| 28. | Frank DiPino | 9/14/1981 |
| 29. | Dan Duran | 4/17/1981 |
| 30. | Joe Edelen | 4/18/1981 |
| 31. | Marshall Edwards | 4/11/1981 |
| 32. | Dave Engle | 4/14/1981 |
| 33. | Rick Engle | 9/2/1981 |
| 34. | Neil Fiala | 9/3/1981 |
| 35. | Steve Fireovid | 9/6/1981 |
| 36. | Dan Firova | 9/1/1981 |
| 37. | Scott Fletcher | 4/25/1981 |
| 38. | Terry Francona | 8/19/1981 |
| 39. | Mark Funderburk | 9/4/1981 |
| 40. | Gary Gaetti | 9/20/1981 |
| 41. | Danny Garcia | 4/26/1981 |
| 42. | Ron Gardenhire | 9/1/1981 |
| 43. | Mike Gates | 5/6/1981 |
| 44. | Brian Giles | 9/12/1981 |
| 45. | Tom Gorman | 9/2/1981 |
| 46. | David Green | 9/4/1981 |
| 47. | Doug Gwosdz | 8/17/1981 |
| 48. | Albert Hall | 9/12/1981 |
| 49. | Mel Hall | 9/3/1981 |
| 50. | Atlee Hammaker | 8/13/1981 |
| 51. | Greg Harris | 5/20/1981 |
| 52. | Brad Havens | 6/5/1981 |
| 53. | Von Hayes | 4/14/1981 |
| 54. | Dave Henderson | 4/9/1981 |
| 55. | Kevin Hickey | 4/14/1981 |
| 56. | John Hobbs | 8/31/1981 |
| 57. | Dave Hostetler | 9/15/1981 |
| 58. | Mike Howard | 9/12/1981 |
| 59. | Kent Hrbek | 8/24/1981 |
| 60. | Tim Ireland | 9/20/1981 |
| 61. | Brook Jacoby | 9/13/1981 |
| 62. | Bob Johnson | 9/1/1981 |
| 63. | Tony Johnson | 9/27/1981 |
| 64. | Wallace Johnson | 9/8/1981 |
| 65. | Greg Keatley | 9/27/1981 |
| 66. | Gene Krug | 4/29/1981 |
| 67. | Tim Laudner | 8/28/1981 |
| 68. | Rick Leach | 4/30/1981 |
| 69. | Terry Leach | 8/12/1981 |
| 70. | Tim Leary | 4/12/1981 |
| 71. | John Lickert | 9/19/1981 |
| 72. | Rufino Linares | 4/10/1981 |
| 73. | Rick Lisi | 5/9/1981 |
| 74. | Larry Littleton | 4/12/1981 |
| 75. | Bob Long | 9/2/1981 |
| 76. | Steve Lubratich | 9/27/1981 |
| 77. | Candy Maldonado | 9/7/1981 |
| 78. | Jim Maler | 9/3/1981 |
| 79. | Fred Manrique | 8/23/1981 |
| 80. | Mike Marshall | 9/7/1981 |
| 81. | Len Matuszek | 9/3/1981 |
| 82. | Andy McGaffigan | 9/22/1981 |
| 83. | Vance McHenry | 8/13/1981 |
| 84. | Mark Mercer | 9/1/1981 |
| 85. | Kelvin Moore | 8/28/1981 |
| 86. | Angel Moreno | 8/15/1981 |
| 87. | Darryl Motley | 8/10/1981 |
| 88. | Gene Nelson | 5/4/1981 |
| 89. | Tom Niedenfuer | 8/15/1981 |
| 90. | Jack O'Connor | 4/9/1981 |
| 91. | Larry Owen | 8/14/1981 |
| 92. | Casey Parsons | 5/31/1981 |
| 93. | Mike Patterson | 4/15/1981 |
| 94. | Reggie Patterson | 8/13/1981 |
| 95. | Bert Pena | 9/14/1981 |
| 96. | Alejandro Pena | 8/13/1981 |
| 97. | Joe Pittman | 4/25/1981 |
| 98. | Bob Porter | 5/13/1981 |
| 99. | Chuck Porter | 9/14/1981 |
| 100. | Ted Power | 9/9/1981 |
| 101. | Charlie Puleo | 9/16/1981 |
| 102. | Jeff Ransom | 9/5/1981 |
| 103. | Johnny Ray | 9/2/1981 |
| 104. | Jerry Reed | 9/11/1981 |
| 105. | Cal Ripken | 8/10/1981 |
| 106. | Andre Robertson | 9/3/1981 |
| 107. | Ron Roenicke | 9/2/1981 |
| 108. | Gene Roof | 9/3/1981 |
| 109. | Pat Rooney | 9/9/1981 |
| 110. | Larry Rothschild | 9/11/1981 |
| 111. | Willie Royster | 9/3/1981 |
| 112. | Dave Rucker | 4/12/1981 |
| 113. | Paul Runge | 9/25/1981 |
| 114. | Luis Sanchez | 4/10/1981 |
| 115. | Orlando Sanchez | 5/6/1981 |
| 116. | Ryne Sandberg | 9/2/1981 |
| 117. | Steve Sax | 8/18/1981 |
| 118. | Jeff Schattinger | 9/21/1981 |
| 119. | Dave Schmidt | 5/1/1981 |
| 120. | Dave Schmidt | 4/28/1981 |
| 121. | Jeff Schneider | 8/12/1981 |
| 122. | Daryl Sconiers | 9/13/1981 |
| 123. | Ray Searage | 6/11/1981 |
| 124. | Paul Serna | 9/1/1981 |
| 125. | John Shelby | 9/15/1981 |
| 126. | Pat Sheridan | 9/16/1981 |
| 127. | Eric Show | 9/2/1981 |
| 128. | Matt Sinatro | 9/22/1981 |
| 129. | Billy Smith | 6/9/1981 |
| 130. | Bryn Smith | 9/8/1981 |
| 131. | Chris Smith | 5/14/1981 |
| 132. | Ken Smith | 9/22/1981 |
| 133. | Ray Smith | 4/9/1981 |
| 134. | Bob Stoddard | 9/4/1981 |
| 135. | Pat Tabler | 8/21/1981 |
| 136. | Wayne Tolleson | 9/1/1981 |
| 137. | Tim Tolman | 9/9/1981 |
| 138. | Bob Tufts | 8/10/1981 |
| 139. | Greg Wells | 8/10/1981 |
| 140. | Chris Welsh | 4/12/1981 |
| 141. | Len Whitehouse | 9/1/1981 |
| 142. | Tom Wieghaus | 10/4/1981 |
| 143. | Alan Wiggins | 9/4/1981 |
| 144. | Dallas Williams | 9/19/1981 |
| 145. | Mike Witt | 4/11/1981 |
| 146. | Jim Wright | 4/22/1981 |
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